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Growth hormone

MGF / PEG-MGF (mechano growth factor): Effects, Evidence and Risks

Research use only: MGF / PEG-MGF (Mechano Growth Factor) is not approved as a medicine. It is offered as a research substance labelled “for research purposes only – not for use in humans or animals”. This page summarises the state of research and is not a recommendation to use it.

Also known as Mechano growth factor, MGF, IGF-1Ec, PEG-MGF, pegylated MGF.

StatusNot approved
EvidencePreclinical
Drug classSynthetic peptide from an IGF-1 splice variant (C-terminal fragment), sometimes PEGylated · injection
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What is MGF / PEG-MGF (mechano growth factor)?

MGF is a short peptide (24 amino acids) from an IGF-1 splice variant produced in muscle after loading. PEG-MGF is a synthetic variant extended with polyethylene glycol that is meant to stay stable for longer.

How well studied is MGF / PEG-MGF (mechano growth factor)?

The evidence consists almost entirely of cell and animal studies; there are no controlled human studies. Whether injected MGF promotes muscle growth in humans at all is unproven.

What side effects and risks does MGF / PEG-MGF (mechano growth factor) have?

Human safety data are lacking. Because IGF-1 splice variants have been linked to tumour growth, a cancer-promoting effect is under discussion. Grey-market products are untested for purity, sterility and identity.

Is MGF / PEG-MGF (mechano growth factor) approved in Germany?

In short: no. Not approved as a medicine anywhere. Explicitly prohibited in sport (WADA S2, growth factors); may fall under the German AntiDopG. High quality and counterfeit risk.

Sources

Note: We deliberately do not list any doses here. For approved medicines, your doctor sets the dose; for unapproved substances there is no reliable information.