What is Enclomiphene?
Enclomiphene is the trans isomer of clomiphene and likewise works by blocking hypothalamic estrogen receptors, which raises LH, FSH and testosterone. It was developed as a treatment for men with secondary hypogonadism. In the fitness and bodybuilding scene it is marketed as a "testosterone booster" and "PCT" agent.
How well studied is Enclomiphene?
Phase 3 trials showed a rise in testosterone levels but did not adequately examine whether symptoms such as libido, potency, bone or weight improved. The EMA refused marketing authorisation (EnCyzix) in 2018 because the benefits did not outweigh the risks.
What side effects and risks does Enclomiphene have?
The EMA saw a particular risk of venous thromboembolism (blood clots). As with clomiphene, visual disturbances, mood changes and headache are possible. Long-term data are lacking; unapproved products have no verified quality.
Is Enclomiphene approved in Germany?
In short: no. Not approved as a medicine in the EU or the US (EMA refusal 2018). Marketing it as a medicine without authorisation is not permitted in Germany (AMG); offers as a "supplement" or "research chemical" are illegal. WADA: S4 (hormone and metabolic modulators, anti-estrogenic substance) – prohibited at all times.
Sources
- EMA: Refusal of marketing authorisation for EnCyzix (enclomifene) – Q&A
- OPSS: Clomiphene and Enclomiphene – Drugs, Not Dietary Supplements
Note: We deliberately do not list any doses here. For approved medicines, your doctor sets the dose; for unapproved substances there is no reliable information.